The proline-rich domain and the microtubule binding domain of protein tau acting as RNA binding domains.
نویسندگان
چکیده
Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA non-sequence-specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in cells.
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ورودعنوان ژورنال:
- Protein and peptide letters
دوره 13 7 شماره
صفحات -
تاریخ انتشار 2006